Ingenza - Technology

Patents

Method for stereoselectively inverting a chiral centre of a chemical compound using an enzyme and a metal catalyst', (2001), US 6,365,380 B2.

Chemoenzymic deracemization of amines using Aspergillus monoamine oxidase', M. Alexeeva, A. Enright, N.J. Turner, M. Mahmoudian, PCT Int. Appl. (2003), WO 2003080855.

Publications

Amine-Boranes: Effective Reducing Agents for the Deracemisation of DL- α -Amino Acids Using L-Amino Acid Oxidase from Proteus Myxofaciens.
F.-R. Alexandre, D.P. Pantaleone, P.P. Taylor, I.G. Fotheringham, D.J. Ager and N.J. Turner, Tetrahedron Lett., 2002, 43 , 707-711.

Deracemisation and Stereoinversion of α -Amino Acids Using D-Amino Acid Oxidase and Hydride Reducing Agents.
T. Beard and N.J. Turner, Chem Commun., 2002, 246-247.

Deracemisation of α -Methylbenzylamine Using an Enzyme Obtained by In Vitro Evolution.
M. Alexeeva, A. Enright, M.J. Dawson, M. Mahmoudian and N.J. Turner, Angew. Chem. Int. Ed., 2002, 41 , 3177-3180.

Directed Evolution of Enzyme for Applied Biocatalysis.
N.J. Turner , TIBTECH , 2003, 21 , 474-478.

Stereoinversion of β - and γ -Substituted- α -Amino Acids Using a Chemoenzymatic Oxidation-Reduction Procedure.
A. Enright, F.-R. Alexandre, G. Roff, I.G. Fotheringham, M.J. Dawson and N.J. Turner, Chem Commun ., 2003, 2636-2637.

Directed Evolution of an Amine Oxidase Possessing Both Broad Substrate Specificity and High Enantioselectivity.
R. Carr, M. Alexeeva, A. Enright, T.S.C. Eve, M.J. Dawson and N.J. Turner, Angew. Chem. Int. Ed., 2003, 42 , 4807-4810.

Directed Evolution of Enzymes: New Biocatalysts for Asymmetric Synthesis.
M. Alexeeva, R. Carr and N. J. Turner, Org. Biomol. Chem ., 2003, 1 , 4133-4137.

A Versatile Chemo-Enzymatic Route to Enantiomerically Pure β -Branched- α -Amino acids.
G.J. Roff, R.C. Lloyd and N.J. Turner, J. Am. Chem. Soc., 2004, 126 , 4098-4099.

Enzyme Catalysed Deracemisation and Dynamic Kinetic Resolution Reactions.
N.J. Turner, Curr. Opin. Chem. Biol ., 2004, 8 , 114-119.

Articles

Synthetic chemistry and biology in new process development.
sp 2 Magazine , April 2003, 2 , 3, 39-40.

Novel biocatalyst technology for the preparation of chiral amines.
Innovations in Pharmaceutical Technology , 2004, 4 , 14, 114-122.