Success story

Efficient manufacture of first-in-class antimicrobial

Customer challenge

Unable to progress a promising, first-in-class 51-amino acid antimicrobial peptide, due to its high potency resulting in very low yield from recombinant bacterial production.

3D render of a protein structure

Ingenza’s inGenius® solution

Fusion of target to novel, removable, fluorescent reporter, permitting efficient, low-cost manufacture from a P. pastoris host.

>500x

Greater than 500x productivity gain.

3x

3x faster manufacturing process.

Delivered

Highly productive clone isolated by ultra-HTP FACS screening, visual monitoring of productivity and stability, low-cost maturation.

A GMP-compliant, scalable DS manufacturing process, supporting successful formulation and toxicology.

FACS screening figure