Strain / Cell Line Development

At the forefront of biologics innovation, we specialise in designing highly efficient biological solutions. Our expertise spans advanced expression systems for biologics in mammalian, yeast and bacterial hosts.

You can read more about our expertise and success stories below.

codABLE™

Recombinant protein expression is vital in biotechnology to produce many biomolecules. Codon choice greatly influences gene expression, but codon optimisation methods are often unreliable. To solve this problem, we created codABLE™, a machine learning algorithm, which consistently outperforms leading gene synthesis providers in efficiency of heterologous protein production.

codABLE™ allows:

  • Precise gene expression control.
  • Maximising protein expression titres.
  • Accelerating the development of protein therapeutics.
  • Achieving viable biomanufacturing processes through efficient production of heterologous proteins.

Mammalian Cell Line Development

We specialise in the development of high-performing mammalian cell lines, optimised for productivity, stability, and scalability in biopharmaceutical production.

Our services include:

  • Intelligent design of advanced expression systems to optimise cell line productivity and stability.
  • Assembly of expression constructs leveraging our library of genetic elements, royalty-free expression vectors and our codABLE™ machine learning-based gene design algorithm.
  • Cell line transfection and selection.
  • Generation of high-titre stable pools and performance assessment.
  • Single cell sorting and selection of high-performing monoclonal cell lines.
  • Preparation, stability and performance testing of research master banks.

CHO cells

  • Mammalian cell line, human-like post-translational modifications
  • Suitable for complex mammalian protein targets
  • Transient and stable expression systems

Microbial Strain Development

Our microbial strain development services focus on creating robust, high-performing strains optimised for maximum productivity and efficiency in biologics production.

Our services include:

  • Intelligent design of advanced expression systems to optimise cell line productivity and stability.
  • Assembly of expression constructs leveraging our library of genetic elements, royalty-free expression vectors and our codABLE™ machine learning-based gene design algorithm.
  • Cell line transfection and selection.
  • Generation of high-titre stable pools and performance assessment.
  • Single cell sorting and selection of high-performing monoclonal cell lines.
  • Preparation, stability and performance testing of research master banks.

Escherichia coli

  • Gram-negative bacterium
  • History of successful use in pharma manufacture
  • Extensive toolbox of gene expression systems
  • Fully scalable

Bacillus spp.

  • GRAS Gram-positive bacterium
  • Signal sequence library for efficient secretion of protein targets
  • Protease deficient strains
  • Endotoxin-free
  • Fully scalable

Pichia pastoris

  • GRAS
  • Efficient secretion of mammalian therapeutics
  • Very high cell density and productivity
  • Fully scalable

Research Cell Banks

Our mammalian and microbial Research Cell Bank services allow generation and storage of cell banks to support your pre-clinical activities.

Our services include:

  • Generation of Research Master and Working Cell Banks, with secure cryopreservation and storage options to ensure long-term viability and reproducibility.
  • Comprehensive testing, including viability, genetic identity and mono aseptic verification.
  • Performance testing to confirm genetic stability and expression consistency.
  • Full documentation and traceability ensuring data integrity and alignment with regulatory expectations.
Scientists working in a lab