Host Organisms

Ingenza’s diverse range of bacterial, yeast and filamentous fungal production hosts offer tailored, scalable biomanufacturing for applications in enzymes, personal care and sustainable chemicals. The productivity, quality management and process robustness essential for commercial operations using our hosts is underpinned by:

  • Customised feedstock testing and development
  • Statistical design-of-experiments based media and growth optimisation
  • Long-proven culture protocols
  • Master and Working cell banks

Our inGenius® platform hosts

Escherichia coli

  • Gram-negative bacterium
  • History of successful use in pharma manufacture
  • Extensive toolbox of gene expression systems
  • Fully scalable

Bacillus spp.

  • GRAS Gram-positive bacterium
  • Signal sequence library for efficient secretion of protein targets
  • Protease deficient strains
  • Endotoxin-free
  • Fully scalable

Pichia pastoris

  • GRAS
  • Efficient secretion of mammalian therapeutics
  • Very high cell density and productivity
  • Fully scalable

Pseudomonas putida

  • High tolerance to solvents
  • Diverse metabolism
  • Well-defined genetic toolbox

Streptomyces sp.

  • Complex secondary metabolism
  • Producer of numerous medical compounds

Corynebacterium glutamicum

  • Heterologous protein and small molecule secretion
  • High cell-specific productivity

Yarrowia lipolytica

  • Dimorphic fungus, GRAS status
  • Highly amenable to metabolic engineering for lipid and non-lipid chemicals
  • High tolerance to wide range of pH and salt concentrations

Saccharomyces cerevisiae

  • GMP-compliant for pharma
  • GRAS
  • Large toolbox available
  • Highly scalable

Aspergillus niger

  • Capacity to secrete large amounts of enzymes
  • Production of citric acid
  • Various metabolites